Medical Library
145 evidence-based articles + 10 holistic-medicine book reviews — in each of the 3 languages. Endocrinology, metabolism, nutraceuticals, anti-aging. Scientific perspective without populism.
Diabetes & Remission
5
Acarbose (Acarphage): the tablet that works in the gut, not in the blood
Acarbose is one of the few tablets for high blood sugar that barely reaches the blood: it slows the breakdown of starch …
A New Word in Type 2 Diabetes Treatment and NAD+ Activation: Imeglimin
In June 2021, Japan approved a type 2 diabetes tablet unlike any existing class: imeglimin acts on the mitochondrion — t…
Can Type 2 Diabetes Be Cured? A Scientific Look at Remission
"Can type 2 diabetes be cured?" — millions of people ask this question worldwide. The answer depends on what counts as a…
Endocrinology
12
Stress axis: sleep, energy, and which tests to discuss before blaming it all on stress
A guide to the Stress Axis questionnaire: how sleep loss raises evening cortisol and how evening light and caffeine inte…
Orforglipron: the first pill instead of an injection — and what it actually does
Every GLP-1 drug so far has been an injection — not by design but by chemistry: they are proteins, and the stomach diges…
The Autoimmune Protocol (AIP) in Hashimoto's Thyroiditis: What Two Studies Actually Showed
The autoimmune protocol promises what patients want most: stopping the disease with food. Evidence exists — exactly two …
Metabolism & Weight
5
Esafosfina: why it is an energy drip and why it was given to footballers
Esafosfina is an Italian drip of fructose-1,6-diphosphate, a molecule from the middle of the chain in which the cell cha…
MOTS-c: a peptide from the mitochondrion’s own DNA that responds to exertion
The mitochondrion is remembered as the plant that makes energy. It turns out to have a voice as well: inside its own DNA…
Sepiapterin (Sephience) in Phenylketonuria: A Drug Measured by the Plate
In phenylketonuria the enzyme cannot keep up with phenylalanine, which builds up in the blood and poisons the developing…
Thyroid
19
Iron and thyroid pills: why 4 hours, and when to check ferritin
One person can take a thyroid pill and iron if the two are separated in time — though even the gap does not help everyon…
Which Mental Illness Is Linked to Hypothyroidism? Depression, Anxiety, and Hashimoto's
A patient has been on antidepressants for five years with no lasting effect — nobody ever checked TPO antibodies. A case…
TSH Is a Pituitary Hormone, Not a Thyroid Hormone: The Single-Test Blind Spot
When a clinician orders "just TSH" — they measure pituitary function, not thyroid function. TSH is a late, inertial mark…
Supplements & Nutraceuticals
8
Adaptogens by stress type: what the data say and what to check first
A companion guide to the “Stress Type” questionnaire: where the three types and three scenarios come from, and what to r…
Cordyceps and immunity: a review of Das et al., 2021
A review of Das et al. (Frontiers in Pharmacology, 2021): which effects of cordyceps are described, where they were obse…
Amla (10:1 Extract): What the Research Shows, and What Turned Out to Be a Legend
Two kinds of things get written about amla: enthusiastic legends, and nothing. The legends are easy to check — the famou…
Anti-Aging
3
Ten healthy diets compared against biological age. The gap between them is smaller than it looks
German researchers took ten recognised healthy-eating scores — Mediterranean, DASH, MIND, Nordic and others — and matche…
Spontaneous Remissions: Anomaly or Unstudied Mechanism? Alexander (Cureus, 2025) and RRMI
Medicine calls it an anomaly. But the data says otherwise. 60 documented cases of radical remission — unexpected recover…
NAD+ and Cellular Aging: What's Behind the Hype
NAD+ (nicotinamide adenine dinucleotide) is a central coenzyme of energy metabolism whose levels decline by roughly 50% …
Diagnostics
5
Haemochromatosis is not missed in the lab report — most often, the test is simply never ordered
Hereditary haemochromatosis is found late not because it is hard to recognise, but because the right test is most often …
Transferrin saturation: why a single number cannot be trusted
A single high transferrin saturation is not a diagnosis, and not even grounds for genetic testing. In five short pages: …
Ferritin and Hair Loss: How Much Iron Is Actually Needed
"Check your ferritin" is the most common advice given for hair loss, and it is also the most commonly misread result. Fe…
Neurology
24
Modafinil: mechanism, indications and comparison with other wake-promoting agents
A review of modafinil based on labels from the FDA, EMA and other regulators and on research: what is known about the me…
The Strongest Opioid Painkillers: What Potency Actually Means
A list of opioids by potency reads like a ranking: sufentanil, fentanyl, buprenorphine, then the rest. But the study tho…
Suzetrigine (Journavx): The First Non-Opioid Painkiller of a New Class in Decades
For the first time in decades a painkiller has arrived with a genuinely new mechanism: it switches off a sodium channel …
Cardiology
29
Cordyceps and Arrhythmias: A Review of Wang et al., 2022
A meta-analysis of 19 Chinese RCTs showed a signal of benefit from Ningxinbao capsules as an add-on to arrhythmia treatm…
5 foods that lower bad cholesterol: how much to eat and how far LDL falls
Five foods that lower "bad" cholesterol in meta-analyses — LDL cholesterol (low-density lipoprotein): daily amounts, fig…
Elamipretide (Forzinity) in Barth Syndrome: A Drug Approved Despite a Failed Trial
Barth syndrome is a disease of twelve boys in a clinical trial and a few hundred people worldwide. Elamipretide braces t…
Nephrology
12
Migalastat (Galafold) in Fabry Disease: A Capsule Instead of an Infusion — But Not for Everyone
In Fabry disease a lysosomal enzyme is missing, and the substance it should break down piles up in the kidneys, heart an…
Lumasiran (Oxlumo) in Primary Hyperoxaluria: Closing the Tap Above the Fault
In primary hyperoxaluria type 1 the liver manufactures oxalate that the body has nowhere to put: it leaves only through …
Finerenone (Kerendia): A Short Guide to the Drug That Slows Kidney Failure in Diabetes
In type 2 diabetes the kidneys fail quietly: first protein appears in the urine, then filtration drifts downwards for ye…
Gastroenterology
17
RepairGut: what is inside and who it suits
A mini-guide to the RepairGut supplement (Prescription Nature, France): what is in the daily serving, at what doses and …
Berberine for SIBO: first in the ranking, with nothing yet to compare it against
Berberine came first in a network meta-analysis of SIBO treatments — and that is true. But a ranking is not «it beat rif…
SIBO: what the breath test shows, and why the order of steps matters more than the remedy
SIBO is both under-recognised and over-diagnosed, and the same breath test is responsible for each. What it actually mea…
Dermatology
3
Deucravacitinib (Sotyktu): The Psoriasis Tablet That Binds Beside the Lock, Not Inside It
Ordinary JAK inhibitors bind where ATP binds — the enzyme's active site. The trouble is that this site looks similar acr…
Tapinarof (VTAMA): The Non-Steroidal Cream You Can Use on the Face and for as Long as You Need
A steroid ointment works, but it comes with a counter: two weeks, not on the face, not over a large area. Psoriasis and …
Alopecia Areata and Ritlecitinib (Litfulo): A Practical Guide to Diagnosis, Indications and Dosing
Five years ago a patient with total hair loss had almost nothing to be offered: steroid injections, minoxidil, a contact…
Book Reviews
10
Outlive — Peter Attia: three ideas that reshape the approach to longevity
Peter Attia, a physician and longevity researcher, reframes what "treating" means in his book "Outlive" (2023). Three ke…
The Hormone Cure — Sara Gottfried: cortisol, thyroid, and estrogen dominance
Sara Gottfried, a Harvard-trained gynaecologist, formulates three theses in "The Hormone Cure" (2013) that have reshaped…
Why We Sleep — Matthew Walker: four phases, sleep debt and brain clearance
Matthew Walker, a neuroscientist at UC Berkeley, formulates three ideas in "Why We Sleep" (2017): the four phases of sle…
Instagram Post Breakdowns
1
Index of all materials · 155
- Can Type 2 Diabetes Be Cured? A Scientific Look at Remission
- Weight Loss with Type 2 Diabetes: Why Diets Fail and What Actually Works
- Berberine vs Metformin: A Doctor's Evidence-Based Comparison for Type 2 Diabetes
- How to Reverse Prediabetes: The Complete Evidence-Based Guide
- The 7 Best Supplements for Insulin Resistance: Evidence-Based Guide
- HOMA-IR: The Blood Test Your Doctor Isn't Ordering (But Should Be)
- Hypothyroidism and Natural Desiccated Thyroid (NDT): Why Levothyroxine Isn't the Only Option
- Gastritis and Helicobacter pylori: A Complete Natural Treatment Protocol Based on Clinical Evidence
- Cordyceps: Why Wild Himalayan and Lab-Grown Are Two Different Products
- Ozempic and GLP-1 Agonists: The Dark Side of "Miracle Weight Loss Injections"
- Cortisol and Adrenal Health: Why 'Adrenal Fatigue' Isn't a Diagnosis but a Real Problem
- Glutathione: The Master Antioxidant and 3 Phases of Detoxification
- Medicinal Mushrooms: Reishi, Lion's Mane, Cordyceps — What Science Says
- Testosterone in Men Over 40: When TRT Is Truly Necessary
- Menopause Without Suffering: Bioidentical vs Synthetic Hormones
- PCOS: Why "Just Take Birth Control" Is Not Enough
- Migraine: Accurate Diagnosis and Treatment Beyond Painkillers
- Nootropics: What Actually Works for the Brain According to Science
- Insomnia: GABA, Glycine, Magnesium — The Perfect Sleep Formula
- NAD+ and Cellular Aging: What's Behind the Hype
- Cholesterol: When Statins Are NOT Needed and What Works Instead
- Personalized Nutraceuticals: Why "One Vitamin for Everyone" Doesn't Work
- Leaky Gut: Intestinal Permeability — The Root of Autoimmune Disease
- Pregnenolone: 'Mother of All Hormones' for Burnout and Chronic Fatigue
- CGM Sensors: How Real-Time Glucose Monitoring Is Changing Diabetes Treatment
- Low-Dose Lithium: An Unexpected Remedy for Anxiety and Panic Attacks
- CBD Oil: Evidence-Based Benefits for Pain, Anxiety, and Neuroinflammation
- Obesogens: Why Diet and Exercise Are Not Enough. Book Review: Blumberg "The Obesogen Effect"
- Spontaneous Remissions: Anomaly or Unstudied Mechanism? Alexander (Cureus, 2025) and RRMI
- Hyperprolactinemia and Dopamine: When It Is a Pituitary Tumor and When It Is Not
- OCPs and Thyroid: Why "Levothyroxine Just in Case" Is Iatrogenesis
- Iodine and Thyroid: 5-Step Protocol for Proper Use
- Why You Are Not Losing Weight: The Reverse T3 Trap and Survival Mode
- Endothelium: The Foundation of Vascular Health and a 20-Year Window of Reversibility
- Trans Fats and the Heart: Molecules Without a Safe Dose and the Inflammatory Cascade
- 6 Early Markers of Cardiovascular Risk: 10–15 Years Before a Heart Attack
- The Cholesterol Myth: An Extended Lipid Panel Instead of Total Cholesterol
- Alternatives to Stress Testing: Functional Cardiac Risk Assessment Without Radiation
- Blood pressure is not only salt: 6 hidden drivers and a holistic protocol
- The heart as a peptide factory: ANP, BNP, CNP, and the endogenous pharmacopoeia
- Silent Myocardial Ischemia: Why the ECG Is Silent While the Vessels Suffer
- Seven Pillars of Heart Health: A Synchronization Protocol for a Centennial Rhythm
- Low-dose naltrexone (LDN) in Hashimoto thyroiditis: mechanism, dosing, protocol
- T4 → T3 Conversion: Where Deiodinase Fails and What Functional Hypothyroidism Is
- Foods for the heart: 12 daily items — evidence-based nutrition
- Magnesium: 4 forms - glycinate, taurate, malate, threonate - which one to choose
- CAC score: coronary artery calcium as the most accurate heart screening test
- Lp(a) — the genetic cardiovascular risk factor that statins do not treat
- ApoB vs LDL: which marker predicts myocardial infarction more accurately and why the standard lipid panel misses half of the risk
- Sleep Apnea and Atrial Fibrillation: The Missed Link, and Why Ablation Relapses Without CPAP
- Coffee and the Heart: An Evidence-Based Stance and the U-Shaped Risk Curve
- HRV: heart rate variability as a biomarker of autonomic regulation
- Podocyte: foundation of glomerular filtration and a 10-year window for renoprotection
- Microalbuminuria: an early kidney marker and a 10-year window for renoprotection
- Glomerular endothelium: the kidney's vascular filter and the glycocalyx that fails first
- Creatinine Lies: What the Standard Kidney Panel Really Measures and Where Its Blind Spots Are
- NSAIDs and Kidneys: Which Are Safer, Dose Limits, and When to Switch
- PPI and the kidney: CKD risk, acute interstitial nephritis, and when to switch to step-down
- Hepatoprotectors: a myth of post-Soviet pharmacology — what really helps the liver
- ALT Without Symptoms: Silent Liver Diseases That “Normal” Tests Miss
- Lead and the Heart: Heavy Metals as a Hidden Driver of Cardiotoxicity
- Gallbladder, cholestasis, and the sphincter of Oddi: when bile does not flow
- Ferritin and the Liver: Iron, MASLD, and Hereditary Haemochromatosis
- AST/ALT Ratio: What the De Ritis Index Shows
- Outlive — Peter Attia: three ideas that reshape the approach to longevity
- The Hormone Cure — Sara Gottfried: cortisol, thyroid, and estrogen dominance
- Why We Sleep — Matthew Walker: four phases, sleep debt and brain clearance
- The Wahls Protocol — Terry Wahls: mitochondria, nine cups, and the autoimmune spectrum
- Grain Brain — David Perlmutter: sugar, gluten and brain metabolism
- The Hacking of the American Mind — Robert Lustig: dopamine versus serotonin
- In Defense of Food — Michael Pollan: eat food, not too much, mostly plants
- Why Zebras Don't Get Ulcers — Robert Sapolsky: the evolution of stress and Whitehall
- The Body Keeps the Score — Bessel van der Kolk: trauma as somatics and endocrinology
- Spark — John Ratey: exercise as a neuroprotector and a BDNF factory
- Black Cumin (Nigella sativa): 82 Trials, Five Systems of Recovery
- TSH Is a Pituitary Hormone, Not a Thyroid Hormone: The Single-Test Blind Spot
- T3 — the Only Active Thyroid Hormone: Why It Works Inside the Cell
- Stress and the Thyroid: Three Levels of Suppression and the fT3/rT3 Protocol
- Thyroid After Virus: Three Scenarios — Subacute Thyroiditis, Autoimmune Shift, NTIS
- Anti-TPO: The Main Marker of Hashimoto's Thyroiditis and How to Interpret It
- Hashimoto's Thyroiditis: Four Stages of Disease Evolution
- Thyroid Nodules and TIRADS: When Biopsy, When Surveillance
- Selenium 200 mcg for Hashimoto's — The Precise Clinical Dose
- TSH Norms in Pregnancy: Trimester Targets and Clinical Tactics
- Vitamin D and K2 in Hashimoto: the biological pair that decides where calcium goes
- After Thyroidectomy: L-Thyroxine vs NDT — Clinical Criteria for Choosing
- Active Surveillance for Thyroid Cancer: When Cancer Does Not Need Immediate Surgery
- Cognitive Aging: How to Recognize It in Your Thinking Before Others Do
- Which Mental Illness Is Linked to Hypothyroidism? Depression, Anxiety, and Hashimoto's
- Best Liver Supplement for Fatty Liver: What's Actually Proven — Vitamin E, Silymarin, NAC
- Low-Dose Naltrexone (LDN) for Fibromyalgia: Dosing, Evidence, What to Expect
- Psilocybin for depression: what 20 years of research shows, and what changed in 2026
- Pelvic Congestion Syndrome: The Pain a Standard Ultrasound Misses for Years
- A New Word in Type 2 Diabetes Treatment and NAD+ Activation: Imeglimin
- Alopecia Areata and Ritlecitinib (Litfulo): A Practical Guide to Diagnosis, Indications and Dosing
- Ferritin and Hair Loss: How Much Iron Is Actually Needed
- Roxadustat (Evrenzo) for Anaemia of Chronic Kidney Disease: How It Works and What the Trials Showed
- Inclisiran (Leqvio): The Twice-a-Year Cholesterol Injection — What Is Proven and What Is Not
- Setmelanotide (Imcivree): A Short Guide for Rare Forms of Severe Obesity
- Finerenone (Kerendia): A Short Guide to the Drug That Slows Kidney Failure in Diabetes
- Resmetirom (Rezdiffra): The First Drug for Fatty Liver Disease — A Short Guide
- Vonoprazan (Voquezna): An Acid Blocker That Does Not Work Like Omeprazole — A Short Guide
- Daridorexant (Quviviq): A Sleeping Pill That Switches Off Wakefulness Instead of Sedating the Brain
- Mavacamten (Camzyos): A Short Guide to the Drug That Relaxes an Overpowered Heart
- Aficamten (Myqorzo): The Second Generation of Myosin Inhibitors — A Short Guide
- Deucravacitinib (Sotyktu): The Psoriasis Tablet That Binds Beside the Lock, Not Inside It
- Tapinarof (VTAMA): The Non-Steroidal Cream You Can Use on the Face and for as Long as You Need
- Vadadustat (Vafseo): Why a Pill for Kidney Anaemia Was Approved Only for Dialysis Patients
- Sparsentan (Filspari) in IgA Nephropathy: Why Protein in the Urine Fell in Both Diseases but the Indication Came in Only One
- Zuranolone (Zurzuvae): Fourteen Days of Tablets for Postpartum Depression — and Why It Is Not a Pill for Depression in General
- Xanomeline-Trospium (Cobenfy): The First Antipsychotic in 70 Years That Leaves Dopamine Alone
- Efgartigimod (Vyvgart) in Myasthenia Gravis: Switching Off the System That Rescues Harmful Antibodies From Disposal
- Acoramidis (Attruby) in Cardiac Amyloidosis: A Drug Copied From a Protective Mutation
- Vutrisiran (Amvuttra): An Injection Every Three Months That Switches Off Production of the Harmful Protein
- Sotatercept (Winrevair): The First Drug in Pulmonary Hypertension That Treats the Narrowing, Not the Spasm
- Vamorolone (Agamree) in Duchenne Muscular Dystrophy: A Steroid That Does Not Steal Growth
- Migalastat (Galafold) in Fabry Disease: A Capsule Instead of an Infusion — But Not for Everyone
- Sepiapterin (Sephience) in Phenylketonuria: A Drug Measured by the Plate
- Elamipretide (Forzinity) in Barth Syndrome: A Drug Approved Despite a Failed Trial
- Revumenib (Revuforj) in Acute Leukaemia: A Drug That Does Not Kill the Cell but Makes It Grow Up
- Lumasiran (Oxlumo) in Primary Hyperoxaluria: Closing the Tap Above the Fault
- Givosiran (Givlaari) in Acute Hepatic Porphyria: Switching Off Attacks That Should Not Happen
- Mirogabalin (Tarlige) in Neuropathic Pain: The Selectivity That Did Not Abolish Drowsiness
- Zoloft or Cipralex: how the choice is made and how they differ
- Nine supports of a holistic scheme for low mood: substances and body work
- MOTS-c: a peptide from the mitochondrion’s own DNA that responds to exertion
- Vitamin D in hypothyroidism and thyroiditis: doses, injections and monitoring
- Gluten-free diet in Hashimoto's thyroiditis: who it helps and who it does not
- The Autoimmune Protocol (AIP) in Hashimoto's Thyroiditis: What Two Studies Actually Showed
- Suzetrigine (Journavx): The First Non-Opioid Painkiller of a New Class in Decades
- Amla (10:1 Extract): What the Research Shows, and What Turned Out to Be a Legend
- Etoricoxib (Arcoxia): The Strongest Non-Opioid — and What That Actually Means
- Diclofenac: Potassium Versus Sodium — the Difference the Box Does Not Explain
- Metamizole (Dipyrone): Strong, Contested, and Banned in Half the World
- Naproxen: Not the Strongest, but the Longest-Lasting
- Ketoprofen: Twice as Strong in Dental Pain as in Anything Else
- Five Non-Opioid Painkillers: What the Numbers Say and What They Do Not
- The Strongest Opioid Painkillers: What Potency Actually Means
- Four systems worth watching
- Orforglipron: the first pill instead of an injection — and what it actually does
- SIBO: what the breath test shows, and why the order of steps matters more than the remedy
- Berberine for SIBO: first in the ranking, with nothing yet to compare it against
- Ten healthy diets compared against biological age. The gap between them is smaller than it looks
- Transferrin saturation: why a single number cannot be trusted
- Haemochromatosis is not missed in the lab report — most often, the test is simply never ordered
- Iron and thyroid pills: why 4 hours, and when to check ferritin
- 5 foods that lower bad cholesterol: how much to eat and how far LDL falls
- Modafinil: mechanism, indications and comparison with other wake-promoting agents
- Cordyceps and immunity: a review of Das et al., 2021
- Cordyceps and Arrhythmias: A Review of Wang et al., 2022
- RepairGut: what is inside and who it suits
- Stress axis: sleep, energy, and which tests to discuss before blaming it all on stress
- Adaptogens by stress type: what the data say and what to check first
- Acarbose (Acarphage): the tablet that works in the gut, not in the blood
- Esafosfina: why it is an energy drip and why it was given to footballers