in pictures and a few words
What it is and why it matters
Hair has started falling out and nails are splitting? Most often there is an explanation, and the list of tests is short.
- Shedding after an illness, stress, childbirth or a diet is often reversible
- Brittle nails are far from always a lack of vitamins
- Below: which tests to take and when to see a doctor
Why hair doesn’t fall out right away
A hair grows for years, then “rests” for a few months and falls out. An illness, childbirth, sudden weight loss or emotional strain send many hairs to rest at once.
- That’s why hair sheds 2–4 months after the event, and sooner after COVID
- Think back: was there a strict diet 2–4 months before the shedding?
- Hair often grows back, but a long-lasting form also happens
The basic set of tests
The set of tests for hair loss is short. Zinc is added to it when there’s a reason.
- A complete blood count — to check for anemia
- Iron stores, and together with them a test for inflammation
- The hormone used to check the thyroid, and vitamin D
Iron stores
In women whose hair loss leaves no scars on the skin, iron stores are on average lower than in women without hair loss.
- Inflammation inflates the iron-store test — so a test for inflammation is taken alongside it
- How much iron in store hair needs has not been firmly established
- The numbers you come across are practice guides, not proven cut-offs
Honestly. Whether topping up iron helps hair is not yet known. Studies show a link, not proof of a cause.
Vitamin D and zinc
In some studies, vitamin D (in women with certain types of hair loss) and zinc in people with hair loss were on average lower than in those without it.
- This is a link, not a proven cause
- No evidence was found that low zinc causes hair loss
- The normal ranges for both tests are set by the lab
Important. Don’t take iron, zinc or “hair vitamins” blindly: too many supplements can themselves cause hair loss. Without a proven shortage, they are not recommended.
Biotin can distort test results
Biotin can distort blood tests: some results come out falsely high, others falsely low.
- Among the tests checked are the very ones used for hair loss: thyroid, vitamin D, iron stores
- Taking biotin or “hair vitamins”? Tell your doctor before the blood draw
Female-pattern thinning
Hair thins in the middle of the head, while the hairline above the forehead stays. If male hormones are normal, this kind of thinning doesn’t point to an excess of them.
- Checking male hormones is advised with any such thinning
- When there’s a reason, a test for one more hormone, prolactin, is added
- Irregular periods or acne are a reason to discuss hormones and ovaries with a doctor
Brittle nails
Brittle, splitting nails are not rare, more often in older women. And it’s far from always a lack of vitamins.
- It can happen without an obvious cause, or because of an infection, a nail disease or a whole-body illness
- Other causes are injuries and drying out of the nail, so the cause is treated first
- For the nail itself, moisturizers and strengthening coatings can be considered
Who should see a doctor first
It makes sense to see an endocrinologist if the thinning comes with irregular periods, acne or hair growth on the face and body, and also if the thyroid test is out of range.
- Hair falls out in patches, round smooth spots — see a dermatologist
- The skin where hair fell out is red, flaky, painful or shiny — don’t put off the dermatologist
- In clumps, very fast or for longer than six months — see a dermatologist, don’t wait for it to pass on its own
Important. A dark lengthwise stripe on a nail, pain or the nail lifting off is a reason to see a dermatologist.
In one sentence
Recall what happened 2–4 months before the shedding, take the basic tests and tell your doctor about biotin. Shedding after an illness, stress or childbirth is often reversible, though it can also drag on.
Key points
Why hair falls out
Test checklist
| Test | Why | What is looked at |
|---|---|---|
| Complete blood count | To check for anemia | Hemoglobin and red blood cell size |
| Ferritin + ESR (erythrocyte sedimentation rate) or C-reactive protein | Iron stores | 15 µg/L (15 ng/mL) and below — the definition of deficiency in one study; an inflammation marker so that ferritin does not mislead |
| TSH | Thyroid function | Outside the laboratory reference range in either direction |
| Vitamin D — 25-hydroxyvitamin D (25(OH)D) | Vitamin D stores | Level in nmol/L (ng/mL); the normal range is set by the laboratory |
| Serum zinc | Zinc deficiency | In a hair loss study — below 10.7 µmol/L (70 µg/dL); the normal range is set by the laboratory |
| Androgens | Excess of male hormones | In any female pattern thinning |
| Prolactin | Hormonal causes | If indicated |
Brittle nails
Nails split at the edge (onychoschizia), break, crumble and become soft. There is a primary form with no obvious cause and a secondary form — with inflammatory nail diseases, infections, general illnesses, injuries and over-drying of the nail. That is why the cause is treated first; for the nail plate itself, moisturizers and strengthening coatings can be considered, and for the primary form, according to individual reports, biotin, trace elements and amino acids (Chessa MA Dermatol Ther (Heidelb) 2020. PMID 31749091[4]).
What the studies showed
| What was studied | Who took part | Result |
|---|---|---|
| Hair loss after COVID, 2022 | 58 reported cases | Median onset 2 months, recovery 5 months; resolved in 95% |
| Ferritin, meta-analysis, 2022 | 36 observational studies, 10,029 participants in total | Ferritin on average lower in women with hair loss; no replenishment trials |
| Iron deficiency, 2010 | 381 women with hair loss and 76 without | Deficiency common, but no more common than without hair loss |
| Zinc, 2013 | 312 patients and 30 healthy people | Zinc on average lower in patients |
Not everything is clear-cut: the effect of iron replenishment on hair remained unknown (Olsen EA J Am Acad Dermatol 2010. PMID 20947203[7]); a 2002 review found no evidence that low zinc causes hair loss (Rushton DH Clin Exp Dermatol 2002. PMID 12190640[6]). These studies show an association, they do not prove a cause.
Who should be more careful
- Practical advice: if hair falls out in patches — round smooth areas — see a dermatologist.
- Redness, flaking, pain or smooth shiny skin where hair has fallen out are a reason not to put off a visit to a dermatologist.
- If hair falls out in clumps, very quickly or for longer than six months, it is better not to wait for it to pass on its own.
- An androgen check is needed in any female pattern thinning (Carmina E J Clin Endocrinol Metab 2019. PMID 30785992[2]); if irregular periods, acne or hair growth on the face and body have come along with it, it makes sense to see an endocrinologist.
- A dark lengthwise stripe on a nail, pain or the nail lifting off are a reason to see a dermatologist.
- Do not take iron, zinc and “hair vitamins” blindly: excess supplements can themselves cause hair loss, so they are not recommended without a proven deficiency (Rushton DH Clin Exp Dermatol 2002. PMID 12190640[6]).
Bottom line
Think back to what happened 2–4 months before the shedding (after COVID it began earlier; according to a review, after 3–4 months), get the basic set of tests and tell your doctor about biotin. Telogen effluvium is often reversible, although a chronic form also exists. You can go through your results and make a plan at a consultation.
This material is for information only and does not replace a doctor’s consultation. The set of tests and treatment are chosen by a doctor based on an examination and medical history.
References
- Czech T J Cosmet Dermatol 2022. PMID 35801366
- Carmina E J Clin Endocrinol Metab 2019. PMID 30785992
- Treister-Goltzman Y Skin Appendage Disord 2022. PMID 35415182
- Heidelb) 2020. PMID 31749091
- Malkud S J Clin Diagn Res 2015. PMID 26500992
- Rushton DH Clin Exp Dermatol 2002. PMID 12190640
- Olsen EA J Am Acad Dermatol 2010. PMID 20947203
- Rasheed H Skin Pharmacol Physiol 2013. PMID 23428658
- Kil MS Ann Dermatol 2013. PMID 24371385
- Li D JAMA 2017. PMID 28973622
Key facts
- After COVID, the median time to the start of hair shedding was 2 months and to recovery 5 months; it resolved in 95% of 58 reported cases (individual case reports) (Czech T, J Cosmet Dermatol 2022).
- In a meta-analysis of 36 studies (10,029 participants in total), ferritin in women with non-scarring hair loss was on average lower than in women without hair loss; the studies were observational, and the meta-analysis contains no replenishment trials (Treister-Goltzman Y, Skin Appendage Disord 2022).
- Experts advise all women with female pattern hair loss to be checked for androgen excess, and it is desirable to check vitamin D, iron, zinc, thyroid hormones and prolactin (Carmina E, J Clin Endocrinol Metab 2019).
- In 6 healthy adults, 10 mg of biotin a day for a week distorted the results of 9 of 23 assays (Li D, JAMA 2017).
- Brittle nail syndrome affects up to 20% of people, more often women over 50, and the cause is far from always a deficiency (Chessa MA, Dermatol Ther (Heidelb) 2020).





