Evidence-based medicine, practical experience and research by md_pereligyn
"Can type 2 diabetes be cured?" — millions of people ask this question worldwide. Conventional medicine says no, only managed. But clinical research and practice tell a different story.
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High blood sugar is a symptom, not the cause. The real problem is insulin resistance. While you fight symptoms, the disease progresses.
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You're dieting, counting calories, but the weight won't budge. With type 2 diabetes, this is typical. The reason isn't a lack of willpower — it's a hormonal block.
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Prediabetes affects 96 million Americans — one in three adults. The good news? It's the most reversible stage of metabolic dysfunction, with 95%+ success rates when caught early.
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She was 54, had lived with diabetes for 11 years, and was on four medications. They told her the disease was progressive. Five months later, her HbA1c was 5.4% — with zero medications.
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Berberine has been called "nature's metformin" — but how does it actually compare? As a physician who has used both in clinical practice, here's what the evidence shows.
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Not all supplements are created equal. After treating 500+ patients for insulin resistance, these are the 7 compounds backed by both research and clinical results.
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Cordyceps supplements have surged in popularity, but wild Himalayan cordyceps and lab-grown varieties are fundamentally different organisms with distinct chemical profiles. Understanding these differences is essential before choosing a supplement.
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Cannabidiol (CBD) — the non-psychoactive phytocannabinoid from Cannabis sativa — has become one of the most researched molecules in neuropharmacology. We review the evidence base for chronic pain, anxiety, and neuroinflammatory conditions.
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Your doctor measures fasting glucose and HbA1c but never orders fasting insulin or calculates HOMA-IR. That's like checking temperature during pneumonia without doing a chest X-ray. Here's why this simple index is the key to early diagnosis.
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Continuous glucose monitoring (CGM) has revolutionized diabetes management by providing real-time data instead of isolated fingerstick readings. We review the latest sensors, key metrics, and practical use cases.
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Labs are normal but symptoms persist? 15-20% of patients on levothyroxine continue to suffer from fatigue, weight gain, and brain fog. The problem isn't the patient — it's the approach.
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Helicobacter pylori infects roughly half the global population and remains the leading cause of chronic gastritis, peptic ulcers, and a significant risk factor for stomach cancer. With antibiotic resistance rates climbing past 30-40% in many regions, evidence-based natural protocols are gaining clinical relevance.
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Glutathione is a tripeptide present in every cell of the human body and widely considered the master intracellular antioxidant. It participates in all three phases of hepatic detoxification, protects cells from oxidative damage, and is essential for immune function. Why do its levels decline, and what does the science say about restoring them?
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Medicinal mushrooms are among the fastest-growing categories in the nutraceutical industry. But what lies behind the millennia-old tradition: marketing hype or rigorous science? We examine the clinical evidence for Reishi, Lion's Mane, and Cordyceps — from beta-glucans and immune modulation to neurogenesis and cognitive enhancement.
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Standard multivitamins contain nutrients in forms and dosages that ignore individual genetics, microbiome, and current deficiency status. We examine the personalized nutraceutical approach — from blood tests to custom-compounded capsules.
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Increased intestinal permeability — commonly known as leaky gut — is no longer a fringe concept. Peer-reviewed research now places it at the center of autoimmune, metabolic, and neuroinflammatory disease. We examine the evidence and restoration protocols.
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GLP-1 receptor agonists like Ozempic have been hailed as miracle weight loss drugs. But behind the dramatic before-and-after photos lie serious risks — from irreversible stomach paralysis to losing muscle instead of fat.
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The term "adrenal fatigue" dominates integrative medicine discussions, yet it has never been recognized as a legitimate medical diagnosis. The real issue — HPA axis dysregulation — is well-documented in peer-reviewed literature and has measurable biomarkers, distinct phases, and evidence-based treatment protocols.
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After age 40, testosterone declines by 1-2% annually. But age-related decline is not always benign. We examine when TRT is genuinely warranted, which labs are essential, and how to optimize testosterone naturally before committing to lifelong therapy.
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Menopause affects every woman. But hot flashes, insomnia, anxiety, and bone loss are not inevitable. We examine the difference between bioidentical and synthetic hormone therapy, reinterpret the WHI study, and outline a personalized approach to menopausal hormone therapy.
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In 70% of women with PCOS, the root cause is insulin resistance, not a hormonal imbalance. Standard birth control prescriptions mask symptoms without addressing the underlying mechanism. We examine the pathophysiology, proper diagnosis, and a comprehensive treatment protocol.
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Pregnenolone — the precursor to every steroid hormone in the body — occupies a unique position at the intersection of endocrinology and neuroscience. During chronic stress and burnout, its levels decline among the first, triggering a cascade of hormonal disruption.
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Migraine is not "just a headache." It is a neurovascular disease affecting 12% of the population. Standard painkiller treatment leads to medication-overuse headache. We examine accurate diagnosis, the CGRP pathway, and an evidence-based prevention protocol.
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The nootropics market is valued at $6 billion and growing at 15% annually. But which of the hundreds of "smart drugs" are actually supported by clinical evidence? We examine citicoline, Lion's Mane, racetams, and modafinil — from mechanisms to protocols.
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Chronic insomnia affects 10-15% of adults and is associated with increased risk of cardiovascular disease, type 2 diabetes, and dementia. We examine the evidence-based sleep restoration formula: GABA, glycine, magnesium, L-theanine, and melatonin.
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Lithium at therapeutic doses has long been used for bipolar disorder. But microdoses of lithium (5-20 mg elemental) demonstrate remarkable neuroprotective and anxiolytic effects without the side effects of high-dose therapy.
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Total cholesterol and standard LDL are outdated cardiovascular risk markers. LDL particle size, particle count (LDL-P), and ApoB/ApoA1 ratio tell a fundamentally different story. We examine when statins truly are not needed and what works instead.
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NAD+ (nicotinamide adenine dinucleotide) is a central coenzyme of energy metabolism whose levels decline by roughly 50% by age 50. We examine the science behind the hype: sirtuins, NMN vs NR, IV NAD+, epigenetic clocks, and real-world protocols.
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