PCOS (ICD-10 E28.2): Diagnostics, Protocol, Consultation

Polycystic ovary syndrome is a hormonal disorder in which irregular periods and excess androgen levels combine with insulin resistance, present in 70-80% of PCOS patients and considered a key driver of the condition. This page brings together the three steps of working with PCOS — metabolic diagnostics, correction protocol, and the online consultation format — in one place.

Diagnostics for PCOS is built on a panel of 50+ biomarkers: LH, FSH and their ratio, free and total testosterone, SHBG, DHEA-S, 17-OH-progesterone, anti-Müllerian hormone, along with markers of insulin resistance (fasting glucose and insulin, HOMA-IR), a lipid panel, and pelvic ultrasound to assess ovarian structure.

The standard workup most patients receive from a gynecologist — sex hormones and ultrasound — does not capture the metabolic side of PCOS, even though insulin resistance is recognized as a key driver of the condition in most patients. Without assessing insulin, glucose, and lipids, a correction protocol is built blind and fails to address the mechanism behind cycle irregularities and hyperandrogenism.

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