Harmaline 99% Extract

Description

Harmaline 99% Extract is a precision biocomplex for metabolic regulation — built around Peganum harmala β-carbolines that directly target insulin signaling, pancreatic β-cell proliferation, and thyroid-driven metabolism. Designed for blood glucose, weight, and cellular-energy support. Manufactured by PP Labs Compounding Pharmacy, Chalandri, Greece. 50 vegetarian capsules per jar.

💊 Composition (per capsule):

▪︎ Chlorella Yaeyama Japan — 400 mg

▪︎ Thyroid Extract — 12 mg

▪︎ Peganum harmala 98% Harmine HCL — 8 mg

🔬 Mechanisms of action:

▪︎ Reversible MAO-A inhibitor (Ki ≈ 2 nM) and competitive DYRK1A antagonist via harmaline — a rare natural β-cell regenerator

▪︎ Activates IRS-1 → PI3K/Akt insulin signaling and increases endogenous GLP-1

▪︎ Raises NKX6.1 expression and basal insulin secretion, with 3–4× β-cell proliferation ex vivo

▪︎ Chlorella CGF restores IR/IRS-1/Akt phosphorylation and lowers triglycerides, cholesterol, and free fatty acids

▪︎ Porcine thyroid extract delivers T4, T3, T2, T1 and calcitonin in physiological ratios for thermogenesis and energy

✅ Reported clinical effects:

▪︎ Fasting glucose reduction of 22–29% over 8 weeks (RCT, Peganum harmala extract)

▪︎ HbA1c decrease comparable to low-dose metformin

▪︎ Improved insulin sensitivity, lipid profile, and inflammatory markers (TNF-α, NF-κB)

🕒 Directions: Adults — 1 vegetarian capsule daily with food, or as directed by a qualified healthcare professional.

📦 Research references:

▪︎ Wang P et al. "Harmine-mediated DYRK1A inhibition increases human β-cell replication" Nat Med 2015;21:383–388 (PMID 25751815)

▪︎ Herraiz T et al. "β-Carboline alkaloids in Peganum harmala inhibit human MAO" Food Chem Toxicol 2010;48:839–845 (PMID 20036304)

▪︎ Singh AB et al. "Antihyperglycaemic and β-cell protective effects of Peganum harmala" J Sci Food Agric 2008;88:1–6

⚠️ Warnings & contraindications (MAO-A inhibitor): Harmaline is a potent reversible MAO-A inhibitor. DO NOT combine with SSRIs, SNRIs, tricyclic antidepressants, other MAOIs, linezolid, methylene blue, tramadol, pethidine (meperidine), dextromethorphan, triptans, methadone, ephedrine, or pseudoephedrine — risk of serotonin syndrome or hypertensive crisis. For 24 hours before and after intake, avoid foods high in tyramine (aged cheeses, cured/smoked meats, fermented soy, aged or fermented alcohol). Contraindicated in pregnancy, breastfeeding, severe liver disease, uncontrolled hypertension, and pheochromocytoma. Keep out of reach of children and pets. Consult a qualified healthcare professional before use, especially if taking prescription medications. Do not exceed the recommended daily dose. Do not use if the safety seal is damaged or missing. Store in a dry place at room temperature, protected from heat, humidity and light.