Femity 50-7 estradiol-levonorgestrel weekly patch, 4 patches

Description

🇮🇹 Femity 50 mcg/7 mcg/24 ore (Theramex, Italy; AIC 036489019) —

💊 Prescription transdermal patch for continuous combined hormone replacement therapy (HRT) in postmenopausal women more than one year after the last period, with an intact uterus.

▪︎ One 15 cm² patch releases 50 µg estradiol + 7 µg levonorgestrel per 24 h (1.5 mg estradiol hemihydrate + 0.525 mg levonorgestrel per patch)

🕒 One patch for 7 days, changed without a break — 4 patches cover a month; no withdrawal bleeding by design

🔬 Estradiol relieves hot flushes and night sweats and protects bone; levonorgestrel protects the endometrium; the transdermal route bypasses the liver, so the risk of venous thromboembolism is not raised (odds ratio 0.93 in 80 396 cases, BMJ 2019) and thyroxine-binding globulin barely changes (+0.4 % vs +39.9 % on oral conjugated oestrogens)

🧬 Evidence: with the US analogue (estradiol 45 µg + levonorgestrel 15–40 µg/day) hot flushes fell within 2 weeks and endometrial hyperplasia was 0 % vs 12.8 % on estradiol alone (Shulman, Menopause 2002, 1138 women) 💶 Italy: 9.36 € per pack of 4, class A (paid by the national health service, prescription RR); not on the AIFA shortage list of 20.10.2026

⚠️ Prescription drug (Rx): the decision on HRT, the regimen and the dose are the physician's after an examination. Contraindications common to all HRT: breast cancer (current, past or suspected), oestrogen-dependent tumours, undiagnosed genital bleeding, untreated endometrial hyperplasia, venous thromboembolism (current or past), thrombophilia, recent arterial thromboembolic disease, acute liver disease, porphyria.

📦 Ordered on request via chat — availability and current price are confirmed by the administrator. Full guide: /blog/plastyr-estradiol-levonorgestrel-zgt