Delivery 7–10 daysCombiseven 50-10 estradiol-levonorgestrel sequential patches, 2 plus 2
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Description
🇮🇹 Combiseven 2 + 2 (Theramex, Italy; AIC 035392012) —
💊 Prescription transdermal patches for sequential combined hormone replacement therapy (HRT): for women with an intact uterus whose periods still come or whose last period was less than 12 months ago.
▪︎ 28-day pack of 2 + 2: weeks 1–2 — two patches of estradiol 50 µg/24 h; weeks 3–4 — two patches of estradiol 50 µg + levonorgestrel 10 µg/24 h; a withdrawal bleed follows at the end of the cycle
🕒 One patch for 7 days, changed on the same weekday
🔬 Estradiol relieves hot flushes and night sweats and protects bone; levonorgestrel for 12–14 days per cycle protects the endometrium; the transdermal route does not raise the risk of venous thromboembolism (odds ratio 0.93 in 80 396 cases, BMJ 2019) 💶 Italy: ≈10.39 € per pack of 2 + 2, class A; not on the AIFA shortage list of 20.10.2026
⚠️ Prescription drug (Rx): the decision on HRT, the regimen and the dose are the physician's after an examination. Contraindications common to all HRT: breast cancer (current, past or suspected), oestrogen-dependent tumours, undiagnosed genital bleeding, untreated endometrial hyperplasia, venous thromboembolism (current or past), thrombophilia, recent arterial thromboembolic disease, acute liver disease, porphyria.
📦 Ordered on request via chat — availability and current price are confirmed by the administrator. Full guide: /blog/plastyr-estradiol-levonorgestrel-zgt
