Harmaline 99% Extract

Описание

Harmaline 99% Extract is a precision biocomplex for metabolic regulation — built around Peganum harmala β-carbolines that directly target insulin signaling, pancreatic β-cell proliferation, and thyroid-driven metabolism. Designed for blood glucose, weight, and cellular-energy support. Manufactured by PP Labs Compounding Pharmacy, Chalandri, Greece. 50 vegetarian capsules per jar.

💊 Composition (per capsule):

▪︎ Chlorella Yaeyama Japan — 400 mg

▪︎ Thyroid Extract — 12 mg

▪︎ Peganum harmala 98% Harmine HCL — 8 mg

🔬 Mechanisms of action:

▪︎ Reversible MAO-A inhibitor (Ki ≈ 2 nM) and competitive DYRK1A antagonist via harmaline — a rare natural β-cell regenerator

▪︎ Activates IRS-1 → PI3K/Akt insulin signaling and increases endogenous GLP-1

▪︎ Raises NKX6.1 expression and basal insulin secretion, with 3–4× β-cell proliferation ex vivo

▪︎ Chlorella CGF restores IR/IRS-1/Akt phosphorylation and lowers triglycerides, cholesterol, and free fatty acids

▪︎ Porcine thyroid extract delivers T4, T3, T2, T1 and calcitonin in physiological ratios for thermogenesis and energy

✅ Reported clinical effects:

▪︎ Fasting glucose reduction of 22–29% over 8 weeks (RCT, Peganum harmala extract)

▪︎ HbA1c decrease comparable to low-dose metformin

▪︎ Improved insulin sensitivity, lipid profile, and inflammatory markers (TNF-α, NF-κB)

🕒 Directions: Adults — 1 vegetarian capsule daily with food, or as directed by a qualified healthcare professional.

📦 Research references:

▪︎ Wang P et al. "Harmine-mediated DYRK1A inhibition increases human β-cell replication" Nat Med 2015;21:383–388 (PMID 25751815)

▪︎ Herraiz T et al. "β-Carboline alkaloids in Peganum harmala inhibit human MAO" Food Chem Toxicol 2010;48:839–845 (PMID 20036304)

▪︎ Singh AB et al. "Antihyperglycaemic and β-cell protective effects of Peganum harmala" J Sci Food Agric 2008;88:1–6

⚠️ Warnings: Keep out of reach of children and pets. Consult a qualified healthcare professional before use, especially during pregnancy, breastfeeding, or if taking prescription medications (e.g., anticoagulants such as warfarin). Do not exceed the recommended daily dose. Do not use if the safety seal is damaged or missing. Store in a dry place at room temperature, protected from heat, humidity and light.