Delivery 7–10 daysQuviviq (daridorexant) 50 mg tablets
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Description
💊 Prescription hypnotic of a new class — a dual orexin receptor antagonist.
▪︎ Daridorexant 50 mg tablets (25 mg strength also exists)
▪︎ Manufacturer: Idorsia Pharmaceuticals
🔬 How it works: classic hypnotics amplify the GABA system, the brain's main brake, and dim activity broadly. Daridorexant instead blocks orexin — the peptide that holds the brain awake. It does not press the brake, it lifts the accelerator, which is why morning grogginess and effects on coordination are less pronounced. The half-life of about 8 hours is chosen so the drug covers the night and is largely cleared by morning. 📊 Evidence: two phase 3 trials (Lancet Neurology 2022) showed improvement in objective sleep measures and in self-reported daytime functioning versus placebo.
🕒 25 or 50 mg 30 minutes before bed, once per night, only with at least 7 hours available for sleep.
⚠️ Prescription-only, a controlled substance (Schedule IV in the US). Contraindicated in narcolepsy; caution in severe sleep apnoea and with alcohol. Cognitive behavioural therapy remains first line for chronic insomnia — this drug supports it rather than replacing it.
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