OEstrodose estradiol gel

OEstrodose – a hormonal control agent for women during menopause (natural or surgical). The medication helps compensate for the lack of natural estrogens and improves patients' well-being by alleviating menopausal symptoms. It is produced as a gel for transdermal application.

Pharmacological action:
The medication contains 17-beta estradiol, which is identical to the estradiol produced by the female body. During therapy, the condition of the mammary glands, vaginal endometrium and epithelium, pituitary gland, and hypothalamus improves. The gel also affects liver function. The effect of the medication is comparable to that of orally administered estrogens.

Indications:
The transdermal agent is used as part of hormone replacement therapy (HRT) with confirmed estrogen deficiency, including in cases of pronounced climacteric syndrome. During postmenopause, it is recommended to prevent osteoporosis when other medications for fracture prevention cannot be used.

Contraindications:
OEstrodose should not be used in pregnant or breastfeeding women. Other contraindications include:

• Immune hypersensitivity to components
• Hormone-dependent tumors of the reproductive system
• Unexplained bleeding
• Breast cancer
• Acute endometrial hyperplasia
• High risk of venous or arterial thrombosis
• Recent history of myocardial infarction or angina
• Liver tumors
• Congenital hyperbilirubinemia
• Cholestatic pruritus or jaundice
• Blood system diseases

Side effects:
Possible adverse reactions during use include:

• Headache
• Occasional dizziness
• Epigastric pain
• Increased gas formation
• Nausea attacks
• Skin itching
• Breast swelling
• Menorrhagia, dysmenorrhea, leukorrhea, and metrorrhagia
• Weight gain or loss

Dosage regimen:
The transparent gel is used continuously or cyclically. The duration and dosage are determined by the doctor. Usually, 2.5 g of the substance is applied once daily at the beginning of treatment.

Special instructions:
There is no information about the effectiveness in patients over 65 years; thus, it is prescribed in special cases.
Avoid concurrent use with sodium lauryl sulfate and other topical hormonal medications. Also, cosmetic products, especially keratolytics, should not be applied after the gel.

Active ingredients:
17 β-estradiol (calculated as anhydrous estradiol).
Each 1.25 g dose of OESTRODOSE 0.06% contains 0.75 mg estradiol.

Other components:
Carbomer (Carbopol 980 NF), tromamine, ethanol 96% (calculated as anhydrous ethanol), purified water.